Anesthesiology PGx Panel
Test Description
The Anesthesiology PGx Panel is intended for individuals undergoing surgical procedures or receiving anesthesia who may benefit from pharmacogenetic-guided medication management. This panel evaluates clinically relevant genetic variants in the BCHE gene associated with altered metabolism of certain anesthetic agents, particularly mivacurium. Individuals with reduced butyrylcholinesterase activity may be at increased risk for prolonged neuromuscular blockade and delayed recovery following administration of mivacurium. Genetic testing may help identify patients at risk for adverse drug reactions and support safer anesthetic planning and medication selection.
Ordering Information
Turnaround Time: 3-7 business days
Preferred specimens: Saliva
Alternate specimens: Buccal Swab
Clinical Description
Anesthetic agents and perioperative medications may have variable effects depending on an individual’s genetic profile. Genetic variations can influence drug metabolism, efficacy, and risk of adverse reactions, including prolonged sedation or inadequate analgesia. Pharmacogenetics testing can help guide anesthetic planning and optimize medication selection to improve patient safety and perioperative outcomes.
Panel Information
| Medication | Gene |
| Mivacurium | BCHE |
Tagged Genes
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- Cavallari LH, Lee CR, Beitelshees AL, et al. Multisite investigation of outcomes with implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention. JACC Cardiovasc Interv. 2018;11(2):181–191. doi:10.1016/j.jcin.2017.07.022
- Jneid H, Anderson JL, Wright RS, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non–ST-elevation myocardial infarction. Circulation. 2012;126(7):875–910. doi:10.1161/CIR.0b013e318256f1e0
- Scott SA, Sangkuhl K, Stein CM, et al. Clinical Pharmacogenetics Implementation Consortium guidelines for CYP2C19 genotype and clopidogrel therapy: 2013 update. Clin Pharmacol Ther. 2013;94(3):317–323. doi:10.1038/clpt.2013.105
- Johnson JA, Caudle KE, Gong L, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for pharmacogenetics-guided warfarin dosing: 2017 update. Clin Pharmacol Ther. 2017.
- Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group. Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet. 2010;376(9753):1658–1669. doi:10.1016/S0140-6736(10)60310-8
- The SEARCH Collaborative Group. SLCO1B1 variants and statin-induced myopathy—a genomewide study. N Engl J Med. 2008;359(8):789–799. doi:10.1056/NEJMoa0801936
- Clinical Pharmacogenetics Implementation Consortium (CPIC). Genes–drug pairs.
- U.S. Food and Drug Administration. Table of pharmacogenomic biomarkers in drug labeling.