Pain Management PGx Panel

Test Description

The Pain Management PGx Panel is intended for individuals receiving pain management therapies who may benefit from personalized pharmacogenetic-guided medication management. This panel evaluates clinically relevant genetic variants associated with drug metabolism, efficacy, and opioid response for commonly prescribed analgesic medications, including opioids used for acute and chronic pain management. Pharmacogenetic testing may help guide medication selection and dosing, improve pain control, reduce the risk of adverse drug reactions or inadequate analgesic response, and support safer, more effective individualized treatment strategies. Upon completion of testing, patients receive an interpretive pharmacogenetic report and certificate summarizing clinically relevant results and medication-related findings to support ongoing care and future treatment decisions.

Ordering Information

Turnaround Time: 3-7 business days
Preferred specimens: Saliva
Alternate specimens: Buccal Swab

Testing Kit Request Form


Clinical Description

Commonly used pain medications such as narcotics and over the counter pain medications are under influence of genetic make-up of individuals. A standard dose of a pain medication such as codeine may not be effective in one individual while the exact same dose may be toxic for another individual based on their genetic profile. Therefore, determining the genetic make-up of an individual can help with precision prescribing of the medications.


Opioids
MedicationGene
Codeine, Tramadol, Hydrocodone, Oxycodone, OliceridineCYP2D6
Fentanyl, Buprenorphine, OxycodoneCYP3A4, CYP3A5
MethadoneCYP2B6
Alfentanil, Sufentanil, Hydromorphone, Morphine, FentanylOPRM1
Frequency of Cytochrome P450 (CYP2D6) Metabolizer Types in the Population
CytochromePoor metabolizerIntermediate metabolizerNormal metabolizerRapid or ultra-rapid metabolizer
CYP2D64-7%9-35%50-90%2-3%

Frequency of Cytochrome P450 (CYP2D6 and CYP2C19) Metabolizer Types in the Population
CytochromePoor metabolizerIntermediate metabolizerNormal metabolizerRapid or ultra-rapid metabolizer
CYP2C93%30%68%N/A
CYP2C192-20%24-36%14-44%30%
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
MedicationGene
Ibuprofen, Piroxicam, Lornoxicam, Meloxicam, Flurbiprofen, Celecoxib, Diclofenac, TenoxicamCYP2C9
CarisoprodolCYP2C19


Tagged Genes

Primary panel:

7 genes selected


References
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  • Clinical Pharmacogenetics Implementation Consortium (CPIC). Genes–drug pairs. https://cpicpgx.org/genes-drugs
  • U.S. Food and Drug Administration. Table of pharmacogenomic biomarkers in drug labeling. https://www.fda.gov/drugs/science-and-research-drugs/table-pharmacogenomic-biomarkers-drug-labeling